| First Author | Simmons KB | Year | 2012 |
| Journal | Cell Immunol | Volume | 272 |
| Issue | 2 | Pages | 124-9 |
| PubMed ID | 22138498 | Mgi Jnum | J:181373 |
| Mgi Id | MGI:5311097 | Doi | 10.1016/j.cellimm.2011.10.022 |
| Citation | Simmons KB, et al. (2012) Modulation of TCRbeta surface expression during TCR revision. Cell Immunol 272(2):124-9 |
| abstractText | TCR revision is a tolerance mechanism by which self-reactive TCRs expressed by mature CD4(+) peripheral T cells are replaced by receptors encoded by genes generated by post-thymic DNA rearrangement. The downmodulation of surface TCR expression initiates TCR revision, and serves as a likely trigger for the induction of the recombinase machinery. We show here in a Vbeta5 transgenic mouse model system that downregulation of the self-reactive transgene-encoded TCR is not maintained by transgene loss or diminished transcription or translation. The downregulation of surface TCR expression likely occurs in two stages, only one of which requires tolerogen expression. |
