| First Author | Lynch EA | Year | 2003 |
| Journal | J Immunol | Volume | 171 |
| Issue | 10 | Pages | 4965-8 |
| PubMed ID | 14607889 | Mgi Jnum | J:135472 |
| Mgi Id | MGI:3793909 | Doi | 10.4049/jimmunol.171.10.4965 |
| Citation | Lynch EA, et al. (2003) Cutting edge: IL-16/CD4 preferentially induces Th1 cell migration: requirement of CCR5. J Immunol 171(10):4965-8 |
| abstractText | IL-16 binds to CD4 and induces a migratory response in CD4(+) T cells. Although it has been assumed that CD4 is the sole receptor and that IL-16 induces a comparable migratory response in all CD4(+) T cells, this has not been investigated. In this study, we determined that IL-16 preferentially induces a migratory response in Th1 cells. Because chemokine receptor CCR5 is expressed predominantly in Th1 cells and is physically associated with CD4, we investigated whether IL-16/CD4 stimulation was enhanced in the presence of CCR5. Using T cells from CCR5(null) mice, we determined that IL-16-induced migration was significantly greater in the presence of CCR5. The presence of CCR5 significantly increased IL-16 binding vs CD4 alone; however, IL-16 could not bind to CCR5 alone. Because CD4(+)CCR5(+) cells are prevalent at sites of inflammation, this intimate functional relationship likely plays a pivotal role for the recruitment and activation of Th1 cells. |
