| First Author | Heemskerk MH | Year | 1995 |
| Journal | Eur J Immunol | Volume | 25 |
| Issue | 4 | Pages | 1109-12 |
| PubMed ID | 7737281 | Mgi Jnum | J:112983 |
| Mgi Id | MGI:3664161 | Doi | 10.1002/eji.1830250438 |
| Citation | Heemskerk MH, et al. (1995) Activation of virus-specific major histocompatibility complex class II-restricted CD8+ cytotoxic T cells in CD4-deficient mice. Eur J Immunol 25(4):1109-12 |
| abstractText | Acute enteritic or respiratory disease is a consequence of coronavirus infection in man and rodents. Mouse hepatitis virus, stain A59 (MHV-A59) causes acute hepatitis in mice and rats and induces a response of major histocompatibility complex (MHC) class II-restricted CD4+ cytotoxic T cells, protecting mice against acute infection. In the present study we show that MHV-A59 infection of mice that lack a functional CD4 gene activates effector cells of the CD8+ phenotype. These cytotoxic T cells lyse virus-infected target cells in a MHC class II-restricted fashion. The results indicate that CD8+ T cells have the potential to utilize MHC class II as restriction element, illustrating that the immune system can effectively deal with evading microorganisms, such as viruses which down-regulate MHC class I. |
