| First Author | Berke Z | Year | 1996 |
| Journal | Int J Cancer | Volume | 67 |
| Issue | 3 | Pages | 405-8 |
| PubMed ID | 8707416 | Mgi Jnum | J:113042 |
| Mgi Id | MGI:3664375 | Doi | 10.1002/(SICI)1097-0215(19960729)67:3<405::AID-IJC15>3.0.CO;2-6 |
| Citation | Berke Z, et al. (1996) Polyoma tumor development in neonatally polyoma-virus-infected CD4-/- and CD8-/- single knockout and CD4-/-8-/- double knockout mice. Int J Cancer 67(3):405-8 |
| abstractText | CD4-/- or CD8-/- single knockout as well as CD4-/-8-/- double knockout mice were infected with polyoma virus as newborns or 1 week after birth. The animals were followed for tumor development and virus persistence. Double knockout mice developed tumors at a higher incidence (29%) than either the CD8-/- or CD4-/- single knockout mice (11% and 2%, respectively). Persistence of polyoma virus was examined by PCR in one third of all animals included in the study. Seven of the 17 CD4-/-8-/- double knockout mice gave positive evidence of virus persistence up to 6 months p.i. where virus DNA was present in most organs. Corresponding tests in single knockout mice gave positive results of persistent viral DNA in 2 of the 19 CD8-/-and 2 of the 7 CD4-/-mice. In the single knockout mice polyoma DNA could only be detected in a more limited variety of organs compared to the double knockouts. |
