| First Author | Lin X | Year | 2004 |
| Journal | Int Immunol | Volume | 16 |
| Issue | 9 | Pages | 1237-40 |
| PubMed ID | 15262897 | Mgi Jnum | J:91962 |
| Mgi Id | MGI:3051200 | Doi | 10.1093/intimm/dxh125 |
| Citation | Lin X, et al. (2004) CD4+ T cells are important for clearance of DA strain of TMEV from the central nervous system of SJL/J mice. Int Immunol 16(9):1237-40 |
| abstractText | DA and other TO subgroup strains of Theiler's murine encephalomyelitis virus synthesize a protein called L(*) which interferes with DA virus clearance from the central nervous system of susceptible SJL mice, thereby fostering virus persistence and a late demyelinating disease. By using CD4 (-/-) and CD8 (-/-) mice as well as adoptive transfer studies we demonstrate that susceptible mouse strains are capable of clearing DA virus through a CD4+ T cell-dependent activity that is inhibited by L(*). |
