| First Author | Rahemtulla A | Year | 1993 |
| Journal | Philos Trans R Soc Lond B Biol Sci | Volume | 342 |
| Issue | 1299 | Pages | 57-8 |
| PubMed ID | 7904347 | Mgi Jnum | J:20507 |
| Mgi Id | MGI:66501 | Doi | 10.1098/rstb.1993.0135 |
| Citation | Rahemtulla A, et al. (1993) CD4 negative mice as a model for immunodeficiency. Philos Trans R Soc Lond B Biol Sci 342(1299):57-8 |
| abstractText | CD4 is a co-receptor required for T cell helper functions. A mouse strain without CD4 expression has been generated. These animals, surprisingly have a normal CTL response and reduced, but not absent, humoral responses. A new population of MHC class II restricted CD4-CD8-TcR alpha beta+ T cells has emerged which possess helper function potential. These findings have important implications on disease situations where CD4 cells are decreased or absent. |
