| First Author | Wen T | Year | 1998 |
| Journal | Immunol Lett | Volume | 61 |
| Issue | 2-3 | Pages | 187-90 |
| PubMed ID | 9657273 | Mgi Jnum | J:47925 |
| Mgi Id | MGI:1206239 | Doi | 10.1016/s0165-2478(98)00022-4 |
| Citation | Wen T, et al. (1998) Requirement of the CD8+ or CD4+ T lymphocyte subsets for the rejection of lymphoma and fibrosarcoma grafts studied in gene knockout hosts. Immunol Lett 61(2-3):187-90 |
| abstractText | Rejections of the retrovirus induced lymphomas (ALC and RBL-5) and the methylcholanthrene (MCA) induced fibrosarcoma (MC57X) grafts were tested in syngeneic CD8 and CD4 single and double knockout C57BL/6 mice. The results with the lymphomas showed that the CD8+ T cell deficiency prevented the development of rejection response induced by immunization. Deficiency of the CD4+ T subset abrogated also the rejection of ALC. Immunity against the fibrosarcoma cells developed in both type of single knockout mice, but not in the ones which lacked both CD4+ and CD8+ T cells. Thus CD8+ T cells were required for rejection of the lymphoma cells, while the CD4+ T cells only mediated a weak response. In absence of CD8+ T cells, CD4+ T cells were sufficient to reject the fibrosarcoma cells. |
