| First Author | Elzey BD | Year | 2003 |
| Journal | Immunity | Volume | 19 |
| Issue | 1 | Pages | 9-19 |
| PubMed ID | 12871635 | Mgi Jnum | J:84573 |
| Mgi Id | MGI:2668300 | Doi | 10.1016/s1074-7613(03)00177-8 |
| Citation | Elzey BD, et al. (2003) Platelet-mediated modulation of adaptive immunity. A communication link between innate and adaptive immune compartments. Immunity 19(1):9-19 |
| abstractText | Platelets are highly reactive components of the circulatory system with well-documented hemostatic function. Recent studies extend platelet function to modulation of local inflammatory events through the release of chemokines, cytokines, and a number of immunomodulatory ligands, including CD154. We hypothesized that platelet-derived CD154 modulates adaptive immunity. The data reported herein demonstrate that platelets, via CD154, induce dendritic cell maturation, B cell isotype switching, and augment CD8(+) T cell responses both in vitro and in vivo. Platelet transfusion studies demonstrate that platelet-derived CD154 alone is sufficient to induce isotype switching and augment T lymphocyte function during viral infection, leading to enhanced protection against viral rechallenge. Additionally, depletion of platelets in normal mice results in decreased antigen-specific antibody production. |
