| First Author | Elzey BD | Year | 2005 |
| Journal | J Leukoc Biol | Volume | 78 |
| Issue | 1 | Pages | 80-4 |
| PubMed ID | 15899982 | Mgi Jnum | J:99287 |
| Mgi Id | MGI:3581934 | Doi | 10.1189/jlb.1104669 |
| Citation | Elzey BD, et al. (2005) Cooperation between platelet-derived CD154 and CD4+ T cells for enhanced germinal center formation. J Leukoc Biol 78(1):80-4 |
| abstractText | It has been demonstrated previously that platelet-derived CD154 communicates with the adaptive immune compartment, enhancing B and T cell responses in CD154(-/-) mice. The presence of platelets was also shown to be necessary for optimal production of immunoglobulin G (IgG) in normal C57BL/6 mice. These data led us to hypothesize that platelets perform a sentinel function, quickly relaying activating signals to the adaptive immune compartment. Here, we report that platelet-derived CD154 increases serum IgG levels and germinal center formation under conditions where antigen-specific CD4(+) T cell numbers are limiting. We propose that in the physiologic setting where antigen-specific B and T cells are rare, platelets function to enhance signals required for robust adaptive humoral immunity. |
