| First Author | MacDonald AS | Year | 2002 |
| Journal | J Immunol | Volume | 168 |
| Issue | 9 | Pages | 4643-9 |
| PubMed ID | 11971013 | Mgi Jnum | J:76160 |
| Mgi Id | MGI:2178726 | Doi | 10.4049/jimmunol.168.9.4643 |
| Citation | MacDonald AS, et al. (2002) Impaired Th2 Development and Increased Mortality During Schistosoma mansoni Infection in the Absence of CD40/CD154 Interaction. J Immunol 168(9):4643-9 |
| abstractText | The role of CD40/CD154 interaction during infection has primarily focused on pathogens that drive inflammatory Th1 responses. In this study, we show that CD40/CD154 interaction is a fundamental requirement for Th2 response development to the parasitic helminth Schistosoma mansoni. Compared with infected wild-type mice, greatly reduced levels of Th2-associated cytokines were measured both in vitro and in vivo, and no IgE or IgG1 was detected in infected CD154(-/-) mice. In the absence of an overt Th2 response, no exaggerated Th1 response was mounted by CD154(-/-) mice. Infected CD154(-/-) mice suffered severe morbidity and mortality, even though parasitemias in wild-type and CD154(-/-) mice did not differ significantly. These data indicate that CD40/CD154 interaction is required to allow development of a Th2-dominated immune response to S. mansoni and support the view that failure to develop such a response can have fatal consequences. |
