| First Author | Kawabe T | Year | 2020 |
| Journal | Nat Commun | Volume | 11 |
| Issue | 1 | Pages | 3366 |
| PubMed ID | 32632165 | Mgi Jnum | J:294172 |
| Mgi Id | MGI:6447059 | Doi | 10.1038/s41467-020-17136-1 |
| Citation | Kawabe T, et al. (2020) Requirements for the differentiation of innate T-bet(high) memory-phenotype CD4(+) T lymphocytes under steady state. Nat Commun 11(1):3366 |
| abstractText | CD4(+) T lymphocytes consist of naive, antigen-specific memory, and memory-phenotype (MP) cell compartments at homeostasis. We recently showed that MP cells exert innate-like effector function during host defense, but whether MP CD4(+) T cells are functionally heterogeneous and, if so, what signals specify the differentiation of MP cell subpopulations under homeostatic conditions is still unclear. Here we characterize MP lymphocytes as consisting of T-bet(high), T-bet(low), and T-bet(-) subsets, with innate, Th1-like effector activity exclusively associated with T-bet(high) cells. We further show that the latter population depends on IL-12 produced by CD8alpha(+) type 1 dendritic cells (DC1) for its differentiation. Finally, our data demonstrate that this tonic IL-12 production requires TLR-MyD88 signaling independent of foreign agonists, and is further enhanced by CD40-CD40L interactions between DC1 and CD4(+) T lymphocytes. We propose that optimal differentiation of T-bet(high) MP lymphocytes at homeostasis is driven by self-recognition signals at both the DC and Tcell levels. |
