| First Author | Medler TR | Year | 2023 |
| Journal | Sci Rep | Volume | 13 |
| Issue | 1 | Pages | 6277 |
| PubMed ID | 37072485 | Mgi Jnum | J:335080 |
| Mgi Id | MGI:7465858 | Doi | 10.1038/s41598-023-33508-1 |
| Citation | Medler TR, et al. (2023) Tumor resident memory CD8 T cells and concomitant tumor immunity develop independently of CD4 help. Sci Rep 13(1):6277 |
| abstractText | Tissue resident memory (Trm) CD8 T cells infiltrating tumors represent an enriched population of tumor antigen-specific T cells, and their presence is associated with improved outcomes in patients. Using genetically engineered mouse pancreatic tumor models we demonstrate that tumor implantation generates a Trm niche that is dependent on direct antigen presentation by cancer cells. However, we observe that initial CCR7-mediated localization of CD8 T cells to tumor draining lymph nodes is required to subsequently generate CD103(+) CD8 T cells in tumors. We observe that the formation of CD103(+) CD8 T cells in tumors is dependent on CD40L but independent of CD4 T cells, and using mixed chimeras we show that CD8 T cells can provide their own CD40L to permit CD103(+) CD8 T cell differentiation. Finally, we show that CD40L is required to provide systemic protection against secondary tumors. These data suggest that CD103(+) CD8 T cell formation in tumors can occur independent of the two-factor authentication provided by CD4 T cells and highlight CD103(+) CD8 T cells as a distinct differentiation decision from CD4-dependent central memory. |
