| First Author | García-Fernández RA | Year | 2011 |
| Journal | Lab Invest | Volume | 91 |
| Issue | 11 | Pages | 1634-42 |
| PubMed ID | 21876534 | Mgi Jnum | J:177185 |
| Mgi Id | MGI:5294472 | Doi | 10.1038/labinvest.2011.133 |
| Citation | Garcia-Fernandez RA, et al. (2011) Combined loss of p21(waf1/cip1) and p27(kip1) enhances tumorigenesis in mice. Lab Invest 91(11):1634-42 |
| abstractText | The cell cycle inhibitors p21(Waf1/Cip1) and p27(Kip1) are frequently downregulated in many human cancers, and correlate with a worse prognosis. We show here that combined deficiency in p21 and p27 proteins in mice is linked to more aggressive spontaneous tumorigenesis, resulting in a decreased lifespan. The most common tumors developed in p21p27 double-null mice were endocrine, with a higher incidence of pituitary adenomas, pheochromocytomas and thyroid adenomas. The combined absence of p21 and p27 proteins delays the incidence of radiation-induced thymic lymphomas with a higher apoptotic rate, measured by active caspase-3 and cleaved PARP-1 immunoexpresion. These results provide experimental evidence for a cooperation of both cyclin-dependent kinase inhibitors in tumorigenesis in mice. |
