| First Author | Mueller CF | Year | 2009 |
| Journal | Arch Biochem Biophys | Volume | 488 |
| Issue | 1 | Pages | 76-82 |
| PubMed ID | 19508861 | Mgi Jnum | J:154247 |
| Mgi Id | MGI:4367529 | Doi | 10.1016/j.abb.2009.06.002 |
| Citation | Mueller CF, et al. (2009) The heterogenous nuclear riboprotein S1-1 regulates AT1 receptor gene expression via transcriptional and posttranscriptional mechanisms. Arch Biochem Biophys 488(1):76-82 |
| abstractText | The AT1 receptor plays an essential role in the pathogenesis of atherosclerosis. AT1 receptor expression is predominately mediated via mRNA destabilization by mRNA binding proteins. We identified via MALDI-analysis the heterogenous nuclear riboprotein S1-1 as an important regulator of AT1 receptor mRNA stability. The S1-1 protein possesses multiple nucleolar and cellular functions in vascular smooth muscle cells (VSMC). Overexpression of S1-1 sense resulted in VSMC in significant stabilization of AT1 receptor mRNA. However, this stabilization of the AT1 receptor mRNA is accompanied by a significantly reduced AT1 receptor mRNA transcription as shown via nuclear run-on assay resulting finally in reduced AT1 receptor mRNA levels. Additionally, S1-1 overexpression leads to increased apoptosis in VSMC and decreases VSMC proliferation. |
