| First Author | Tarakhovsky A | Year | 1995 |
| Journal | Science | Volume | 269 |
| Issue | 5223 | Pages | 535-7 |
| PubMed ID | 7542801 | Mgi Jnum | J:89249 |
| Mgi Id | MGI:3039224 | Doi | 10.1126/science.7542801 |
| Citation | Tarakhovsky A, et al. (1995) A role for CD5 in TCR-mediated signal transduction and thymocyte selection. Science 269(5223):535-7 |
| abstractText | CD5 is a transmembrane protein that is expressed on the surface of T cells and a subset of B cells. The absence of CD5 rendered thymocytes hyperresponsive to stimulation through the T cell antigen receptor (TCR) in vitro. Selection of T cells expressing three distinct transgenic TCRs was also abnormal in CD5-deficient mice. These observations indicate that CD5 can influence the fate of developing thymocytes by acting as a negative regulator of TCR-mediated signal transduction. |
