| First Author | Wei B | Year | 2008 |
| Journal | Eur J Immunol | Volume | 38 |
| Issue | 12 | Pages | 3411-25 |
| PubMed ID | 19009526 | Mgi Jnum | J:141389 |
| Mgi Id | MGI:3818203 | Doi | 10.1002/eji.200838432 |
| Citation | Wei B, et al. (2008) Resident enteric microbiota and CD8(+) T cells shape the abundance of marginal zone B cells. Eur J Immunol 38(12):3411-3425 |
| abstractText | Since enteric microbial composition is a distinctive and stable individual trait, microbial heterogeneity may confer lifelong, non-genetic differences between individuals. Here we report that C57BL/6 mice bearing restricted flora microbiota, a distinct but diverse resident enteric microbial community, are numerically and functionally deficient in marginal zone (MZ) B cells. Surprisingly, MZ B-cell levels are minimally affected by germ-free conditions or null mutations of various TLR signaling molecules. In contrast, MZ B-cell depletion is exquisitely dependent on cytolytic CD8(+) T cells, and includes targeting of a cross-reactive microbial/endogenous MHC class 1B antigen. Thus, members of certain enteric microbial communities link with CD8(+) T cells as a previously unappreciated mechanism that shapes innate immunity dependent on innate-like B cells. |
