| First Author | Zhang S | Year | 2009 |
| Journal | Eur J Immunol | Volume | 39 |
| Issue | 5 | Pages | 1252-9 |
| PubMed ID | 19338001 | Mgi Jnum | J:148099 |
| Mgi Id | MGI:3843541 | Doi | 10.1002/eji.200839152 |
| Citation | Zhang S, et al. (2009) CD4+ T-cell-mediated anti-tumor immunity can be uncoupled from autoimmunity via the STAT4/STAT6 signaling axis. Eur J Immunol 39(5):1252-9 |
| abstractText | Previous reports have suggested that autoimmune sequelae may be an unavoidable consequence of successful immunization against tumor-associated antigens, which are typically non-mutated self-antigens. Using a melanoma model, we demonstrated that CD4(+) T-cell-mediated anti-tumor immunity and autoimmunity could be separated by modulating the STAT4/STAT6 signaling axis. Our results have revealed an unexpected dichotomy in the effector phase following cancer vaccination where anti-tumor immunity is mediated via a STAT6 and IL-4-dependent pathway, whereas autoimmune pathology is mediated via STAT4 through a mechanism that relies partially on IFN-gamma. Our results offer a possibility to elicit specific anti-tumor responses without triggering unwanted tissue autoimmune diseases. |
