| First Author | Yao S | Year | 2011 |
| Journal | Immunity | Volume | 34 |
| Issue | 5 | Pages | 729-40 |
| PubMed ID | 21530327 | Mgi Jnum | J:172609 |
| Mgi Id | MGI:5008357 | Doi | 10.1016/j.immuni.2011.03.014 |
| Citation | Yao S, et al. (2011) B7-h2 is a costimulatory ligand for CD28 in human. Immunity 34(5):729-40 |
| abstractText | CD28 and CTLA-4 are cell surface cosignaling molecules essential for the control of T cell activation upon the engagement of their ligands B7-1 and B7-2 from antigen-presenting cells. By employing a receptor array assay, we have demonstrated that B7-H2, best known as the ligand of inducible costimulator, was a ligand for CD28 and CTLA-4 in human, whereas these interactions were not conserved in mouse. B7-H2 and B7-1 or B7-2 interacted with CD28 through distinctive domains. B7-H2-CD28 interaction was essential for the costimulation of human T cells' primary responses to allogeneic antigens and memory recall responses. Similar to B7-1 and B7-2, B7-H2 costimulation via CD28 induced survival factor Bcl-xL, downregulated cell cycle inhibitor p27(kip1), and triggered signaling cascade of ERK and AKT kinase-dependent pathways. Our findings warrant re-evaluation of CD28 and CTLA-4's functions previously attributed exclusively to B7-1 and B7-2 and have important implications in therapeutic interventions against human diseases. |
