| First Author | Watanabe M | Year | 2022 |
| Journal | Cell Rep | Volume | 41 |
| Issue | 9 | Pages | 111731 |
| PubMed ID | 36450247 | Mgi Jnum | J:337606 |
| Mgi Id | MGI:7407966 | Doi | 10.1016/j.celrep.2022.111731 |
| Citation | Watanabe M, et al. (2022) Antigen-presenting T cells provide critical B7 co-stimulation for thymic iNKT cell development via CD28-dependent trogocytosis. Cell Rep 41(9):111731 |
| abstractText | Invariant natural killer T (iNKT) cell development in the thymus depends on T cell receptor recognition of CD1d ligand on CD4/CD8 double-positive thymocytes. We previously reported that B7-CD28 co-stimulation is required for thymic iNKT cell development, but the cellular and molecular mechanisms underlying this co-stimulatory requirement are not understood. Here we report that CD28 expression on CD1d-expressing antigen-presenting T cells is required for thymic iNKT cell development. Mechanistically, antigen-presenting T cells provide co-stimulation through an unconventional mechanism, acquiring B7 molecules via CD28-dependent trogocytosis from B7-expressing thymic epithelial cells, dendritic cells, and B cells and providing critical B7 co-stimulation to developing iNKT cells. Thus, the present study demonstrates a mechanism of B7 co-stimulation in thymic T cell development by antigen-presenting T cells. |
