| First Author | So T | Year | 2007 |
| Journal | J Immunol | Volume | 179 |
| Issue | 3 | Pages | 1427-30 |
| PubMed ID | 17641007 | Mgi Jnum | J:149955 |
| Mgi Id | MGI:3849407 | Doi | 10.4049/jimmunol.179.3.1427 |
| Citation | So T, et al. (2007) Cutting edge: OX40 inhibits TGF-beta- and antigen-driven conversion of naive CD4 T cells into CD25+Foxp3+ T cells. J Immunol 179(3):1427-30 |
| abstractText | Naive CD4 T cells can develop into regulatory T cells by acquiring the transcription factor Foxp3. Combined signals from the TCR, CD28, IL-2R, and TGF-beta R promote Foxp3 expression in activated naive CD25(-) CD4 T cells. Here we show that OX40 (CD134) signaling inhibits TGF-beta-driven Foxp3 mRNA and suppresses the conversion of naive Ag-specific transgenic CD4 T cells into CD25(+)Foxp3(+) T cells. These data identify OX40 as a negative regulator of Foxp3 and suggest that OX40 can concomitantly promote effector T cell generation while antagonizing the differentiation of adaptive Foxp3(+) regulatory T cells. |
