| First Author | Walunas TL | Year | 1994 |
| Journal | Immunity | Volume | 1 |
| Issue | 5 | Pages | 405-13 |
| PubMed ID | 7882171 | Mgi Jnum | J:189426 |
| Mgi Id | MGI:5445503 | Doi | 10.1016/1074-7613(94)90071-x |
| Citation | Walunas TL, et al. (1994) CTLA-4 can function as a negative regulator of T cell activation. Immunity 1(5):405-13 |
| abstractText | CD28 and CTLA-4 are related glycoproteins found on T cells. Ligation of CD28 following antigen receptor engagement provides a costimulatory signal required for T cell activation. Anti-CTLA-4 antibodies were generated to examine the role of the CTLA-4 receptor on murine T cells. Expression of CTLA-4 as a homodimer is up-regulated 2-3 days following T cell activation. Anti-CTLA-4 antibodies and Fab fragments augmented T cell proliferation in an allogeneic MLR. However, when optimal costimulation and Fc cross-linking were present, anti-CTLA-4 Mabs inhibited T cell proliferation. Together, these results suggest that the MAb may obstruct the interaction of CTLA-4 with its natural ligand and block a negative signal, or directly signal T cells to down-regulate immune function. |
