| First Author | Tang Q | Year | 2003 |
| Journal | J Immunol | Volume | 171 |
| Issue | 7 | Pages | 3348-52 |
| PubMed ID | 14500627 | Mgi Jnum | J:120383 |
| Mgi Id | MGI:3706465 | Doi | 10.4049/jimmunol.171.7.3348 |
| Citation | Tang Q, et al. (2003) Cutting edge: CD28 controls peripheral homeostasis of CD4+CD25+ regulatory T cells. J Immunol 171(7):3348-52 |
| abstractText | CD28/B7 blockade leads to exacerbated autoimmune disease in the nonobese diabetic mouse strain as a result of a marked reduction in the number of CD4(+)CD25(+) regulatory T cells (Tregs). Herein, we demonstrate that CD28 controls both thymic development and peripheral homeostasis of Tregs. CD28 maintains a stable pool of peripheral Tregs by both supporting their survival and promoting their self-renewal. CD28 engagement promotes survival by regulating IL-2 production by conventional T cells and CD25 expression on Tregs. |
