| First Author | Cacalano G | Year | 1994 |
| Journal | Science | Volume | 265 |
| Issue | 5172 | Pages | 682-4 |
| PubMed ID | 8036519 | Mgi Jnum | J:19570 |
| Mgi Id | MGI:67739 | Doi | 10.1126/science.8036519 |
| Citation | Cacalano G, et al. (1994) Neutrophil and B cell expansion in mice that lack the murine IL-8 receptor homolog. Science 265(5172):682-4 |
| abstractText | Interleukin-8 (IL-8) is a proinflammatory cytokine that specifically attracts and activates human neutrophils. A murine gene with a high degree of homology to the two known human IL-8 receptors was cloned and then deleted from the mouse genome by homologous recombination in embryonic stem (ES) cells. These mice, although outwardly healthy, had lymphadenopathy, resulting from an increase in B cells, and splenomegaly, resulting from an increase in metamyelocytes, band, and mature neutrophils. Thus, this receptor may participate in the expansion and development of neutrophils and B cells. This receptor was the major mediator of neutrophil migration to sites of inflammation and may provide a potential therapeutic target in inflammatory disease. |
