| First Author | Matthies H | Year | 1997 |
| Journal | Neuroreport | Volume | 8 |
| Issue | 16 | Pages | 3533-5 |
| PubMed ID | 9427321 | Mgi Jnum | J:103731 |
| Mgi Id | MGI:3610662 | Doi | 10.1097/00001756-199711100-00023 |
| Citation | Matthies H, et al. (1997) Dopamine D1-deficient mutant mice do not express the late phase of hippocampal long-term potentiation. Neuroreport 8(16):3533-5 |
| abstractText | The possible involvement of the dopamine D1 receptor subtype in mechanisms of long-term potentiation (LTP) of the Schaffer collateral-commissural input of CA1 neurones was investigated using D1-deficient mutant mice. In transversal hippocampus slices from mice lacking the D1 receptor a normal post-tetanic and short-term potentiation could be induced after applying a triple 100 Hz tetanization. However, the potentiated fEPSP in the mutant mice declined to control value about 140 min following tetanization, whereas in the wild type mice a normal, non-decremental LTP was observed. These data support the idea that besides the glutamatergic system, the synergistic activation of dopaminergic synapses is necessary for LTP maintenance. |
