| First Author | Bucolo C | Year | 2012 |
| Journal | Biochem Pharmacol | Volume | 83 |
| Issue | 5 | Pages | 680-6 |
| PubMed ID | 22178719 | Mgi Jnum | J:181898 |
| Mgi Id | MGI:5314326 | Doi | 10.1016/j.bcp.2011.11.031 |
| Citation | Bucolo C, et al. (2012) Dopamine- receptor modulates intraocular pressure: implications for glaucoma. Biochem Pharmacol 83(5):680-6 |
| abstractText | The aim of the present study was to investigate the role of D receptor on intraocular pressure regulation using WT and KO DR/ mice. Both mice were used with normal eye pressure or steroid-induced ocular hypertension. As measured by tonometry, the topical application of 7-OH-DPAT, a dopamine D-preferring receptor agonist, significantly decreased, in a dose-dependent manner, the intraocular pressure in WT mice both in an ocular normotensive group and an ocular hypertensive group. Pretreatment with U-99194A, a D receptor antagonist, reverted 7-OH-DPAT induced ocular hypotension in WT mice. No change of intraocular pressure was observed after topical application of 7-OH-DPAT in KO DR/ mice. PCR analysis demonstrated the presence of all dopamine receptor genes in eye tissues obtained from WT mice, and the lack of DR mRNAs in KO mice. The present study identified the DR subtype as the most important receptor of the dopaminergic system to modulate intraocular pressure with relevant implications for glaucoma that represents one of the most crippling optic neuropathies. |
