| First Author | Takai T | Year | 1994 |
| Journal | Cell | Volume | 76 |
| Issue | 3 | Pages | 519-29 |
| PubMed ID | 8313472 | Mgi Jnum | J:39248 |
| Mgi Id | MGI:86630 | Doi | 10.1016/0092-8674(94)90115-5 |
| Citation | Takai T, et al. (1994) FcR gamma chain deletion results in pleiotrophic effector cell defects. Cell 76(3):519-29 |
| abstractText | The gamma subunit of immunoglobulin Fc receptors is an essential component of the high-affinity receptor for IgG (Fc gamma RIII) and is associated with the high-affinity receptor for IgG (Fc gamma RI) and the T cell receptor-CD3 complex. It is required for both receptor assembly and signal transduction. Targeted disruption of this subunit results in immunocompromised mice. Activated macrophages from gamma chain-deficient mice unexpectedly lack the ability to phagocytose antibody-coated particles, despite normal binding. Defects in NK cell-mediated antibody-dependent cytotoxicity and mast cell-mediated allergic responses are evident in these animals, establishing the indispensable role of FcRs in these responses. However, loss of gamma chain does not appear to perturb T cell development, since both thymic and peripheral T cell populations appear normal. These mice thus represent an important tool for evaluating the role of these receptors in humoral and cellular immune responses. |
