| First Author | Aubin É | Year | 2011 |
| Journal | Clin Immunol | Volume | 141 |
| Issue | 3 | Pages | 273-83 |
| PubMed ID | 21824820 | Mgi Jnum | J:178253 |
| Mgi Id | MGI:5297762 | Doi | 10.1016/j.clim.2011.06.009 |
| Citation | Aubin E, et al. (2011) Prevention of T cell activation by interference of internalized intravenous immunoglobulin (IVIg) with MHC II-dependent native antigen presentation. Clin Immunol 141(3):273-83 |
| abstractText | Activation of self-reactive CD4(+) T cells plays a central role in the initiation and maintenance of autoimmune diseases. We recently reported that intravenous immunoglobulin (IVIg) inhibits the MHC II-restricted CD4(+) T cell activation induced by the presentation of immune complexes. Because native antigens can also play a role in the induction of several autoimmune diseases, we determined whether IVIg could also affect CD4(+) T cell activation following presentation of native antigens by APCs. Here we report that IVIg significantly reduces the activation of CD4(+) T cells by native ovalbumin. The inhibitory effect is FcgammaR-independent and occurs following internalization of IVIg inside APCs, where it interferes with the intracellular events leading to MHC II-dependent antigen presentation. The effect of IVIg on native antigen presentation could therefore contribute to dampen the autoimmune reaction by reducing CD4(+) T cell activation and the subsequent inflammatory response induced by these cells. |
