| First Author | de Andres B | Year | 1999 |
| Journal | Immunol Lett | Volume | 68 |
| Issue | 1 | Pages | 109-13 |
| PubMed ID | 10397164 | Mgi Jnum | J:55958 |
| Mgi Id | MGI:1339823 | Doi | 10.1016/s0165-2478(99)00038-3 |
| Citation | de Andres B, et al. (1999) A regulatory role for Fc gamma receptors (CD16 and CD32) in hematopoiesis. Immunol Lett 68(1):109-13 |
| abstractText | Progenitor cells of the T- and B-lineages in mice express (CD32) and Fc gamma RIII (CD16) but as the developing lymphocytes begin to express clonal antigen receptors, CD16 and CD32 are downregulated in T-cells, and CD16 is downregulated in B-cells. Considering that counter-receptors for Fc gamma R occur on thymic and bone marrow stromal cells, the possibility exists that Fc gamma R might participate in some aspect of T- and B-lineage development prior to the stage of antigen receptor expression. Previous studies provided evidence that Fc gamma R can influence murine T-lineage development. In the present studies we found that anti-Fc gamma RII/III mAb accelerated B-lineage development in bone marrow cultures from normal mice, but not in cultures from CD16-/- or CD32-/- mice. Similar results were observed when FACS-purified B-progenitor cells were co-cultured with BMS2, a bone marrow stromal cell line. Fresh bone marrow from CD32-/- mice contained about two-fold more B-lineage cells compared to bone marrow from normal or CD16-/- mice. These studies indicate that the Fc gamma R on B-lineage progenitor cells can influence their further development and add to a growing body of evidence that implicates Fc gamma R as regulatory elements in hematopoiesis. |
