| First Author | Ostrovskaya OI | Year | 2020 |
| Journal | Hippocampus | Volume | 30 |
| Issue | 12 | Pages | 1298-1312 |
| PubMed ID | 32894631 | Mgi Jnum | J:358346 |
| Mgi Id | MGI:7713394 | Doi | 10.1002/hipo.23257 |
| Citation | Ostrovskaya OI, et al. (2020) Developmental onset of enduring long-term potentiation in mouse hippocampus. Hippocampus 30(12):1298-1312 |
| abstractText | Analysis of long-term potentiation (LTP) provides a powerful window into cellular mechanisms of learning and memory. Prior work shows late LTP (L-LTP), lasting >3 hr, occurs abruptly at postnatal day 12 (P12) in the stratum radiatum of rat hippocampal area CA1. The goal here was to determine the developmental profile of synaptic plasticity leading to L-LTP in the mouse hippocampus. Two mouse strains and two mutations known to affect synaptic plasticity were chosen: C57BL/6J and Fmr1(-/y) on the C57BL/6J background, and 129SVE and Hevin(-/-) (Sparcl1(-/-) ) on the 129SVE background. Like rats, hippocampal slices from all of the mice showed test pulse-induced depression early during development that was gradually resolved with maturation by 5 weeks. All the mouse strains showed a gradual progression between P10-P35 in the expression of short-term potentiation (STP), lasting </=1 hr. In the 129SVE mice, L-LTP onset (>25% of slices) occurred by 3 weeks, reliable L-LTP (>50% slices) was achieved by 4 weeks, and Hevin(-/-) advanced this profile by 1 week. In the C57BL/6J mice, L-LTP onset occurred significantly later, over 3-4 weeks, and reliability was not achieved until 5 weeks. Although some of the Fmr1(-/y) mice showed L-LTP before 3 weeks, reliable L-LTP also was not achieved until 5 weeks. L-LTP onset was not advanced in any of the mouse genotypes by multiple bouts of theta-burst stimulation at 90 or 180 min intervals. These findings show important species differences in the onset of STP and L-LTP, which occur at the same age in rats but are sequentially acquired in mice. |
