| First Author | Janusz A | Year | 2013 |
| Journal | J Neurosci | Volume | 33 |
| Issue | 46 | Pages | 18234-41 |
| PubMed ID | 24227732 | Mgi Jnum | J:204168 |
| Mgi Id | MGI:5529742 | Doi | 10.1523/JNEUROSCI.2207-13.2013 |
| Citation | Janusz A, et al. (2013) The Fragile X mental retardation protein regulates matrix metalloproteinase 9 mRNA at synapses. J Neurosci 33(46):18234-41 |
| abstractText | Activity-dependent protein synthesis at synapses is dysregulated in the Fragile X syndrome (FXS). This process contributes to dendritic spine dysmorphogenesis and synaptic dysfunction in FXS. Matrix Metalloproteinase 9 (MMP-9) is an enzyme involved in activity-dependent reorganization of dendritic spine architecture and was shown to regulate spine morphology in a mouse model of FXS, the Fmr1 knock-out mice. Here we show that MMP-9 mRNA is part of the FMRP complex and colocalizes in dendrites. In the absence of FMRP MMP-9 mRNA translation is increased at synapses, suggesting that this mechanism contributes to the increased metalloproteinase level at synapses of Fmr1 knock-out mice. We propose that such a local effect can contribute to the aberrant dendritic spine morphology observed in the Fmr1 knock-out mice and in patients with FXS. |
