| First Author | O'Donnell C | Year | 2017 |
| Journal | Elife | Volume | 6 |
| PubMed ID | 29019321 | Mgi Jnum | J:249663 |
| Mgi Id | MGI:5924023 | Doi | 10.7554/eLife.26724 |
| Citation | O'Donnell C, et al. (2017) Beyond excitation/inhibition imbalance in multidimensional models of neural circuit changes in brain disorders. Elife 6:e26724 |
| abstractText | A leading theory holds that neurodevelopmental brain disorders arise from imbalances in excitatory and inhibitory (E/I) brain circuitry. However, it is unclear whether this one-dimensional model is rich enough to capture the multiple neural circuit alterations underlying brain disorders. Here, we combined computational simulations with analysis of in vivo two-photon Ca2+ imaging data from somatosensory cortex of Fmr1 knock-out (KO) mice, a model of Fragile-X Syndrome, to test the E/I imbalance theory. We found that: (1) The E/I imbalance model cannot account for joint alterations in the observed neural firing rates and correlations; (2) Neural circuit function is vastly more sensitive to changes in some cellular components over others; (3) The direction of circuit alterations in Fmr1 KO mice changes across development. These findings suggest that the basic E/I imbalance model should be updated to higher dimensional models that can better capture the multidimensional computational functions of neural circuits. |
