| First Author | Jain J | Year | 1994 |
| Journal | Mol Cell Biol | Volume | 14 |
| Issue | 3 | Pages | 1566-74 |
| PubMed ID | 8114694 | Mgi Jnum | J:16901 |
| Mgi Id | MGI:64959 | Doi | 10.1128/mcb.14.3.1566 |
| Citation | Jain J, et al. (1994) Normal peripheral T-cell function in c-Fos-deficient mice. Mol Cell Biol 14(3):1566-74 |
| abstractText | The ubiquitous transcription factors Fos and Jun are rapidly induced in T cells stimulated through the T-cell antigen receptor and regulate transcription of cytokines, including interleukin 2, in activated T cells. Since positive and negative selection of thymocytes during T-cell development also depends on activation through the T-cell receptor, Fos and Jun may play a role in thymocyte development as well. Fos and Jun act at several regulatory elements in the interleukin 2 promoter, including the AP-1 and NFAT sites. Using antisera specific to individual Fos and Jun family members, we show that c-Fos as well as other Fos family members are present in the inducible AP-1 and NFAT complexes of activated murine T cells. Nevertheless, c-Fos is not absolutely required for the development or function of peripheral T cells, as shown by using mice in which both copies of the c-fos gene were disrupted by targeted mutagenesis. c-Fos-deficient mice were comparable to wild-type mice in their patterns of thymocyte development and in the ability of their peripheral T cells to proliferate and produce several cytokines in response to T-cell receptor stimulation. Our results suggest that other Fos family members may be capable of substituting functionally for c-Fos during T-cell development and cytokine gene transcription in activated T cells. |
