| First Author | Shearman LP | Year | 1997 |
| Journal | Brain Res Mol Brain Res | Volume | 47 |
| Issue | 1-2 | Pages | 275-85 |
| PubMed ID | 9221926 | Mgi Jnum | J:41519 |
| Mgi Id | MGI:893997 | Doi | 10.1016/s0169-328x(97)00058-2 |
| Citation | Shearman LP, et al. (1997) Haloperidol regulates neurotensin gene expression in striatum of c-fos-deficient mice. Brain Res Mol Brain Res 47(1-2):275-85 |
| abstractText | The immediate-early gene c-fos has been proposed to play a role in induction of neurotensin/neuromedin N (NT/N) gene expression in the striatum following acute haloperidol (HAL) treatment. We utilized mice with targeted disruption of the c-fos gene to directly test this hypothesis. A robust increase in NT/N gene expression was observed in the dorsolateral striatum (DLSt) in both wild-type (WT) and c-fos-deficient mice 4-6 h after a single injection of HAL (1 or 4 mg/kg) indicating that products of the c-fos gene are not absolutely required for induction of NT/N mRNA. The basal expression of preprotachykinin, preproenkephalin and preprocholecystokinin mRNAs did not differ between WT and c-fos knockout mice. HAL treatment first increased striatal NT/N mRNA on postnatal day (PD) 10. HAL-induced NT/N mRNA levels were significantly lower in c-fos knockout mice than in WT mice on PD 10 and 15. These findings indicate that reliance on c-fos may be greater earlier in development and that redundant molecular pathways can lead to induction of NT/N mRNA in mouse striatum. |
