| First Author | Monfort V | Year | 1998 |
| Journal | Behav Brain Res | Volume | 91 |
| Issue | 1-2 | Pages | 165-72 |
| PubMed ID | 9578449 | Mgi Jnum | J:47221 |
| Mgi Id | MGI:1202806 | Doi | 10.1016/s0166-4328(97)00113-7 |
| Citation | Monfort V, et al. (1998) Timed active avoidance learning in lurcher mutant mice. Behav Brain Res 91(1-2):165-72 |
| abstractText | Lurcher mutant mice (+ /Lc) which exhibit a massive loss of neurons in the cerebellar cortex and in the inferior olivary nuclei were subjected to an active avoidance learning task; the animals' avoidance response must occur within a small time window after a short or a long delay. The control mice needed a mean of 8.3 sessions of 10 trials (short delay group) and of 11.8 sessions (long delay group) and showed good retention after a 24 h interval. When subjected to the same number of sessions, the + /Lc mice were unable to learn the timing task. However, a subgroup of lurcher mutants was able to learn after a high number of sessions (25.4 sessions as a mean). There was no intergroup difference in the standard version of one-way active avoidance. These results indicate that the cerebellar cortex is involved in time processing during active avoidance. The cerebellum may be part of a loop including the cerebral cortex known to be involved in time perception. An alternative explanation is that the cerebellar mutant animals had persevering tendencies acquired during performance of the one-way avoidance task. (C) 1998 Elsevier Science B.V. All rights reserved. |
