| First Author | Morii E | Year | 1992 |
| Journal | Brain Res Dev Brain Res | Volume | 65 |
| Issue | 1 | Pages | 123-6 |
| PubMed ID | 1372540 | Mgi Jnum | J:2006 |
| Mgi Id | MGI:50530 | Doi | 10.1016/0165-3806(92)90016-p |
| Citation | Morii E, et al. (1992) Spatial expression of genes encoding c-kit receptors and their ligands in mouse cerebellum as revealed by in situ hybridization. Brain Res Dev Brain Res 65(1):123-6 |
| abstractText | Expression of mRNA for c-kit receptors and their ligands was examined in the cerebellum of mice by in situ hybridization technique. The c-kit receptors were expressed in the molecular layer of the cerebellum and the ligands for the c-kit receptors were detected at the boundary of molecular and granular layers. The expression of the c-kit ligands was not detectable in the cerebellum of lurcher (Lc/+) mutant mice that lack Purkinje cells, indicating the cells expressing the c-kit ligands were Purkinje cells. The cells expressing c-kit receptors decreased but were present in the cerebellum of Lc/+ mice. The c-kit mRNA-positive cells appeared to represent basket cells and stellate cells from their appearance and location. Since neurons in the molecular layer construct suppressive neurojunctions with Purkinje cells, the present result suggests that c-kit receptors and their ligands may play an important role for the construction of their junctions. |
