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Publication : Interaction of granule, Purkinje and inferior olivary neurons in lurcher chimeric mice. II. Granule cell death.

First Author  Wetts R Year  1982
Journal  Brain Res Volume  250
Issue  2 Pages  358-62
PubMed ID  7171994 Mgi Jnum  J:6913
Mgi Id  MGI:55385 Doi  10.1016/0006-8993(82)90431-0
Citation  Wetts R, et al. (1982) Interaction of granule, Purkinje and inferior olivary neurons in lurcher chimeric mice. II. Granule cell death. Brain Res 250(2):358-62
abstractText  Lurcher in equilibrium ichthyosis chimeric mice were constructed to determine whether the death of cerebellar granule cells in lurcher mutants is caused by intrinsic or extrinsic factors. Quantitative analysis demonstrates that more lurcher granule cells survive in the chimeras than would have in the mutants themselves. Thus the granule cell death is an indirect consequence of the lurcher gene acting on some other cell type, probably the cerebellar Purkinje cells.
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