| First Author | Kawa G | Year | 1994 |
| Journal | J Am Soc Nephrol | Volume | 4 |
| Issue | 12 | Pages | 2040-9 |
| PubMed ID | 7919157 | Mgi Jnum | J:19339 |
| Mgi Id | MGI:67508 | Doi | 10.1681/ASN.V4122040 |
| Citation | Kawa G, et al. (1994) Sodium pump distribution is not reversed in the DBA/2FG-pcy, polycystic kidney disease model mouse. J Am Soc Nephrol 4(12):2040-9 |
| abstractText | Recently, it has been reported that Na,K-ATPase in the renal epithelia of human autosomal dominant polycystic kidney disease and cpk mouse, a murine model of autosomal recessive polycystic kidney disease, mislocates to apical plasma membrane and that mislocated Na,K-ATPase causes the cyst formation. Whether the DBA/2FG-pcy mice, which are presumably a suitable model for autosomal dominant polycystic kidney disease, also exhibit the reversal polarity of Na,K-ATPase localization was examined. Kidneys of newborn DBA/2FG-pcy mice, and those at early and late stages of cyst development were examined by immunohistochemical techniques. At any stage, abnormal distribution of Na,K-ATPase on the apical membranes of tubular epithelial cells could not be detected. It is suggested that cysts can be formed without reversed polarity of Na,K-ATPase distribution in pcy mice. |
