| First Author | Beier DR | Year | 1989 |
| Journal | Genomics | Volume | 4 |
| Issue | 4 | Pages | 498-504 |
| PubMed ID | 2744761 | Mgi Jnum | J:9878 |
| Mgi Id | MGI:58335 | Doi | 10.1016/0888-7543(89)90272-3 |
| Citation | Beier DR, et al. (1989) Perinatal lethality (ple): a mutation caused by integration of a transgene into distal mouse chromosome 15. Genomics 4(4):498-504 |
| abstractText | We have used cytogenetic and recombinational analysis to determine the position of a transgene integrated into the mouse genome. The transgene maps to band F on the physical map of mouse chromosome 15 by in situ analysis and is tightly linked genetically to a cluster of loci that include the mutations caracul (Ca) and microcytic anemia (mk). Genetic analysis of the offspring of noninbred animals carrying the transgene and marker loci demonstrates a significant deficiency of homozygous progeny at weaning. When inbred mice heterozygous for the transgene are mated, about one-quarter of their offspring are homozygous; none of these animals survives more than 1 day after birth. It appears likely that a recessive insertional mutation has occurred as a result of transgene integration into a locus required for postnatal viability. We call this mutation transgenic perinatal lethality (Tg.ple). |
