| First Author | Minami SS | Year | 2012 |
| Journal | Neurobiol Aging | Volume | 33 |
| Issue | 4 | Pages | 825.e15-24 |
| PubMed ID | 21741124 | Mgi Jnum | J:188201 |
| Mgi Id | MGI:5439688 | Doi | 10.1016/j.neurobiolaging.2011.05.014 |
| Citation | Minami SS, et al. (2012) Fyn knock-down increases Abeta, decreases phospho-tau, and worsens spatial learning in 3xTg-AD mice. Neurobiol Aging 33(4):825.e15-24 |
| abstractText | Fyn kinase phosphorylates tau and exacerbates amyloid beta (Abeta)-mediated synaptic dysfunction. However, Fyn also increases the nonpathological cleavage of amyloid precursor protein (APP), suggesting opposing roles for Fyn in the pathogenesis of Alzheimer's disease (AD). To determine the effect of Fyn on both Abeta and tau pathologies, we crossed homozygous Alzheimer's disease triple transgenic (3xTg) mice harboring mutations in amyloid precursor protein, presenilin-1, and tau with wild-type or Fyn knockout mice to generate Fyn(+/+)3xTg(+/-) or Fyn(+/-)3xTg(+/-) mice. We found that Fyn(+/-)3xTg(+/-) mice had increased soluble and intracellular Abeta, and these changes were accompanied by impaired performance on the Morris water maze at 18 months. Fyn(+/-)3xTg(+/-) mice had decreased phosphorylated tau at 15-18 months (as did Fyn knockout mice), but Fyn(+/-)3xTg(+/-) mice had increased phosphorylated tau by 24 months. In addition, we observed that Fyn(+/-)3xTg(+/-) males were delayed in developing Abeta pathology compared with females, and displayed better spatial learning performance at 18 months. Overall, these findings suggest that loss of Fyn at early stages of disease increases soluble Abeta accumulation and worsens spatial learning in the absence of changes in tau phosphorylation. |
