| First Author | Tamura T | Year | 2001 |
| Journal | J Immunol | Volume | 167 |
| Issue | 4 | Pages | 1962-9 |
| PubMed ID | 11489976 | Mgi Jnum | J:110880 |
| Mgi Id | MGI:3641484 | Doi | 10.4049/jimmunol.167.4.1962 |
| Citation | Tamura T, et al. (2001) Impairment in the expression and activity of Fyn during differentiation of naive CD4+ T cells into the Th2 subset. J Immunol 167(4):1962-9 |
| abstractText | We previously showed that the amounts of Fyn protein in Th2 clones were approximately one-third to one-fifth of those in Th1 clones. In this study we examined the role of Fyn in the polarization of naive CD4+ T cells toward the Th2 subset using fyn(-/-) mice. The fyn(-/-) naive CD4+ T cells efficiently produced Th2 cytokines and polarized toward the Th2 subset even in the absence of IL-4 and IL-13. The expression of Fyn in wild-type CD4+ T cells decreased at a transcription level concomitant with polarization toward the Th2 subset. These results suggest that Fyn plays a role in the down-regulation of the differentiation of naive CD4+ T cells into the Th2 subset. |
