| First Author | Martín-Cófreces NB | Year | 2006 |
| Journal | J Immunol | Volume | 176 |
| Issue | 7 | Pages | 4201-7 |
| PubMed ID | 16547257 | Mgi Jnum | J:129875 |
| Mgi Id | MGI:3770339 | Doi | 10.4049/jimmunol.176.7.4201 |
| Citation | Martin-Cofreces NB, et al. (2006) Role of Fyn in the rearrangement of tubulin cytoskeleton induced through TCR. J Immunol 176(7):4201-7 |
| abstractText | The translocation of the microtubule-organizing center (MTOC), its associated signaling complex, and the secretory apparatus is the most characteristic early event that involves the tubulin cytoskeleton of T or NK cells after their interaction with APC or target cells. Our results show that Fyn kinase activity is essential for MTOC reorientation in an Ag-dependent system. Moreover, T cells from Fyn-deficient mice are unable to rearrange their tubulin cytoskeleton in response to anti-CD3-coated beads. Analysis of conjugates of T cells from transgenic OT-I mice with dendritic cells revealed that an antagonist peptide induces translocation of the MTOC, and that this process is impaired in T cells from Fyn(-/-) OT-I mice. In addition, Fyn deficiency significantly affects the MTOC relocation mediated by agonist peptide stimulation. These results reveal Fyn to be a key regulator of tubulin cytoskeleton reorganization in T cells. |
