| First Author | Parravicini V | Year | 2002 |
| Journal | Nat Immunol | Volume | 3 |
| Issue | 8 | Pages | 741-8 |
| PubMed ID | 12089510 | Mgi Jnum | J:109153 |
| Mgi Id | MGI:3626017 | Doi | 10.1038/ni817 |
| Citation | Parravicini V, et al. (2002) Fyn kinase initiates complementary signals required for IgE-dependent mast cell degranulation. Nat Immunol 3(8):741-8 |
| abstractText | Fc epsilon RI activation of mast cells is thought to involve Lyn and Syk kinases proximal to the receptor and the signaling complex organized by the linker for activation of T cells (LAT). We report here that Fc epsilon RI also uses a Fyn kinase-dependent pathway that does not require Lyn kinase or the adapter LAT for its initiation, but is necessary for mast cell degranulation. Lyn-deficiency enhanced Fyn-dependent signals and degranulation, but inhibited the calcium response. Fyn-deficiency impaired degranulation, whereas Lyn-mediated signaling and calcium was normal. Thus, Fc epsilon RI-dependent mast cell degranulation involves cross-talk between Fyn and Lyn kinases. |
