| First Author | Seddon B | Year | 2003 |
| Journal | Nat Immunol | Volume | 4 |
| Issue | 7 | Pages | 680-6 |
| PubMed ID | 12808452 | Mgi Jnum | J:129178 |
| Mgi Id | MGI:3768850 | Doi | 10.1038/ni946 |
| Citation | Seddon B, et al. (2003) Interleukin 7 and T cell receptor signals regulate homeostasis of CD4 memory cells. Nat Immunol 4(7):680-6 |
| abstractText | Immunological memory depends on the long-term maintenance of memory T cells. Although the factors that maintain CD8 T cell memory are well understood, those responsible for CD4 memory are not well defined. We have shown here that interleukin 7 (IL-7) was an important survival factor for CD4 memory T cells that together with T cell receptor (TCR) signals regulated homeostasis of the CD4 memory population in lymphopenic conditions and in the intact immune system. Thus, IL-7 contributes to the maintenance of all naive and memory T cell subsets, and therefore controls the overall size of the T cell pool. |
