| First Author | Wang J | Year | 1997 |
| Journal | J Exp Med | Volume | 186 |
| Issue | 7 | Pages | 1171-6 |
| PubMed ID | 9314566 | Mgi Jnum | J:111820 |
| Mgi Id | MGI:3654886 | Doi | 10.1084/jem.186.7.1171 |
| Citation | Wang J, et al. (1997) Essential lymphocyte function associated 1 (LFA-1): intercellular adhesion molecule interactions for T cell-mediated B cell apoptosis by Fas/APO-1/CD95. J Exp Med 186(7):1171-6 |
| abstractText | B cells are susceptible to Fas ligand (FasL)+ CD4(+) Th1 cell-mediated apoptosis. We demonstrate that blocking the interactions between lymphocyte function associated (LFA)-1 and intercellular adhesion molecule(ICAM)-1 and ICAM-2 completely suppresses Fas-dependent B cell lysis. Antibodies to CD2 and CD48 partially suppress B cell apoptosis, whereas anti-B7.1 and anti-B7.2 antibodies have no effect. Also, B cells from ICAM-1-deficient mice are resistant to FasL+ T cell-mediated death. Our results suggest that LFA-1/ICAM interactions are crucial for Th1 cell-mediated B cell apoptosis and may contribute to the maintenance of B cell homeostasis in vivo. |
