| First Author | Dai J | Year | 2008 |
| Journal | J Virol | Volume | 82 |
| Issue | 8 | Pages | 4164-8 |
| PubMed ID | 18256150 | Mgi Jnum | J:153306 |
| Mgi Id | MGI:4361976 | Doi | 10.1128/JVI.02621-07 |
| Citation | Dai J, et al. (2008) Icam-1 participates in the entry of west nile virus into the central nervous system. J Virol 82(8):4164-8 |
| abstractText | Determining how West Nile virus crosses the blood-brain barrier is critical to understanding the pathogenesis of encephalitis. Here, we show that ICAM-1(-/-) mice are more resistant than control animals to lethal West Nile encephalitis. ICAM-1(-/-) mice have a lower viral load, reduced leukocyte infiltration, and diminished neuronal damage in the brain compared to control animals. This is associated with decreased blood-brain barrier leakage after viral infection. These data suggest that ICAM-1 plays an important role in West Nile virus neuroinvasion and that targeting ICAM-1 signaling may help control viral encephalitis. |
