| First Author | Flynn JL | Year | 1995 |
| Journal | J Immunol | Volume | 155 |
| Issue | 5 | Pages | 2515-24 |
| PubMed ID | 7650381 | Mgi Jnum | J:28196 |
| Mgi Id | MGI:75821 | Doi | 10.4049/jimmunol.155.5.2515 |
| Citation | Flynn JL, et al. (1995) IL-12 increases resistance of BALB/c mice to Mycobacterium tuberculosis infection. J Immunol 155(5):2515-24 |
| abstractText | IL-12, a cytokine produced by macrophages and B cells, has recently been found to exert pleiotropic effects on the immune system. When BALB/c mice, a strain highly susceptible to virulent Mycobacterium tuberculosis infection, were given IL-12 at the initiation of infection with M. tuberculosis, their mean survival time doubled from 58 to 112 days. IL-12-treated mice had diminished bacterial burdens, whereas treatment with exogenous IFN-gamma had no effect on survival or bacterial burden. IL-12 treatment also delayed lung pathology in BALB/c mice. In contrast with the findings in the BALB/c model, IL-12 did not increase survival of M. tuberculosis-infected gko mice, transgenic mice in which the IFN-gamma gene has been disrupted, indicating that IL-12 does not induce protection against tuberculosis in mice in the absence of IFN-gamma. |
