| First Author | Enzler T | Year | 2003 |
| Journal | J Exp Med | Volume | 197 |
| Issue | 9 | Pages | 1213-9 |
| PubMed ID | 12732663 | Mgi Jnum | J:83086 |
| Mgi Id | MGI:2656692 | Doi | 10.1084/jem.20021258 |
| Citation | Enzler T, et al. (2003) Deficiencies of GM-CSF and interferon gamma link inflammation and cancer. J Exp Med 197(9):1213-9 |
| abstractText | Chronic inflammation contributes to carcinogenesis, but the underlying mechanisms are poorly understood. We report that aged granulocyte-macrophage colony stimulating factor (GM-CSF)-deficient mice develop a systemic lupus erythematosis (SLE)-like disorder associated with the impaired phagocytosis of apoptotic cells. Concurrent deficiency of interferon (IFN)-gamma attenuates the SLE, but promotes the formation of diverse hematologic and solid neoplasms within a background of persistent infection and inflammation. Whereas activated B cells show a resistance to fas-induced apoptosis, antimicrobial therapy prevents lymphomagenesis and solid tumor development. These findings demonstrate that the interplay of infectious agents with cytokine-mediated regulation of immune homeostasis is a critical determinant of cancer susceptibility. |
