| First Author | Jouanguy E | Year | 1999 |
| Journal | Curr Opin Immunol | Volume | 11 |
| Issue | 3 | Pages | 346-51 |
| PubMed ID | 10375558 | Mgi Jnum | J:55697 |
| Mgi Id | MGI:1339221 | Doi | 10.1016/s0952-7915(99)80055-7 |
| Citation | Jouanguy E, et al. (1999) IL-12 and IFN-gamma in host defense against mycobacteria and salmonella in mice and men. Curr Opin Immunol 11(3):346-51 |
| abstractText | The development of gene-knockout mice and the identification of gene-deficient humans have improved our understanding of the role of IL-12 and IFN-gamma in host defense. Comparison of experimental and natural infections has shown that animals and humans genetically deficient in immunity mediated by IL-12 or IFN-gamma are highly susceptible to mycobacteria and salmonella. Impaired secretion of, or response to, IFN-gamma is the common pathogenic mechanism that accounts for impaired granuloma formation and uncontrolled growth of bacteria within macrophages. The axis formed between IL-12 and IFN-gamma is essential for protective immunity against mycobacteria and salmonella in mice and men. |
