| First Author | Badovinac VP | Year | 2000 |
| Journal | Science | Volume | 290 |
| Issue | 5495 | Pages | 1354-8 |
| PubMed ID | 11082062 | Mgi Jnum | J:83176 |
| Mgi Id | MGI:2657121 | Doi | 10.1126/science.290.5495.1354 |
| Citation | Badovinac VP, et al. (2000) Regulation of antigen-specific CD8+ T cell homeostasis by perforin and interferon-gamma. Science 290(5495):1354-8 |
| abstractText | T cell memory depends on factors that regulate expansion and death of these cells after antigenic stimulation. Mice deficient in perforin and interferon-gamma (IFN-gamma) exhibited increased expansion, altered immunodominance, and decreased death of antigen-specific CD8+ T cells after infection with an attenuated strain of Listeria monocytogenes, which was cleared from these mice. Expansion of CD8+ T cells was controlled by perforin, whereas IFN-gamma regulated immunodominance and the death phase. Thus, perforin and IFN-gamma regulate distinct elements of CD8+ T cell homeostasis independently of their role as antimicrobial effector molecules. |
