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Publication : Role of tumor necrosis factor alpha in development of immunity against Cryptosporidium parvum infection.

First Author  Lean IS Year  2006
Journal  Infect Immun Volume  74
Issue  7 Pages  4379-82
PubMed ID  16790816 Mgi Jnum  J:110124
Mgi Id  MGI:3639431 Doi  10.1128/IAI.00195-06
Citation  Lean IS, et al. (2006) Role of tumor necrosis factor alpha in development of immunity against Cryptosporidium parvum infection. Infect Immun 74(7):4379-4382
abstractText  Tumor necrosis factor (TNF-alpha) significantly reduced Cryptosporidium parvum development in a murine enterocyte cell line, and a key mechanism of action appeared to be inhibition of parasite invasion. However, TNF-alpha-deficient mice controlled infection as effectively as wild-type mice. This suggests that TNF-alpha might have only a redundant role for establishing immunity against C. parvum.
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